David W Deamer
|Division||Physical & Biological Sciences|
|Department||PBSci-Chemistry & Biochemistry Department|
|Office||Physical Sciences, Room 405B|
|Campus Mail Stop||Chemistry|
|1156 High Street|
Santa Cruz, CA
David Deamer's primary research area concerns the manner in which linear macromolecules traverse nanoscopic channels. Single-stranded nucleic acid molecules can be driven electrophoretically through a large channel embedded in a lipid-bilayer membrane, and the presence of the polynucleotide in the channel affects the ionic conductance in a manner related to chain length and concentration. This observation has considerable potential for characterizing DNA and RNA in microscopic volumes of nucleic acid solutions. (See Akeson et al. 1999 and Vercoutere et al. 2001 for recent reports.)
A second line of research concerns molecular self-assembly processes related to the structure and function of biological membranes, and particularly the origin and evolution of membrane structure. One example of such research was reported recently by Dworkin et al. (2001) in which it was shown that photochemical reactions simulating those occurring in the interstellar medium give rise to amphiphilic molecules that can self-assemble into membrane structures. Apel et al. (2001) and Monnard et al., (2002) went on to show that membranes can self-assemble for simple amphiphiles such as fatty acids and alcohols, and that such processes are markedly affected by ionic content of the environment. These results help us to understand how primitive forms of cellular life appeared on the early Earth and were able to capture nutrients from the surrounding medium and incorporate them in intracellular growth processes.
Biography, Education and Training
BSc Chemistry, Duke University, 1961
Ph.D., Ohio State University School of Medicine 1965
Post-doctoral research, UC Berkeley, 1966-67
Asst. Assoc. Full Professor, UC Davis, 1967 - 1994
Research professor, Chemistry and Biochemistry, 1994 - present
Honors, Awards and Grants
Guggenheim Fellow 1986
President, ISSOL 2011 - present
- J. P. Dworkin, D. W. Deamer, S. A. Sandford, and L. J. Allamandola. 2001. Self-assembling amphiphilic molecules: Synthesis in simulated interstellar/precometary ices. Proc. Natl. Acad. Sci. USA 98:815-819.
- Vercoutere, W., S. Winters-Hilt, H. Olsen, D.W. Deamer. D. Haussler, and M. Akeson. 2001. Rapid discrimination among individual DNA molecules at single nucleotide resolution using a nanopore instrument. Nature Biotechnology 19: 248-250.
- Deamer D, Dworkin JP, Sandford SA, Bernstein MP, Allamandola LJ. The first cell membranes. 2002. Astrobiology. 2:371-81.
- Winters-Hilt, S., W. Vercoutere, V. S. DeGuzman, D. Deamer, M. Akeson & D. Haussler. 2003. Highly accurate classification of Watson-Crick base-pairs on termini of single DNA molecules Biophys. J. 84:967-76.
- Vercoutere, W.A., S. Winters-Hilt, V. S. DeGuzman, D. Deamer, S. Ridino, J. T. Rodgers, H. E. Olsen, A. Marziali, and M. Akeson. 2003. Discrimination among individual Watson-Crick base-pairs at the termini of single DNA hairpin molecules. Nucleic Acids Research 31:1311-1318.
Groen J, Deamer DW, Kros A, Ehrenfreund P. 2012. Polycyclic aromatic hydrocarbons as plausible prebiotic membrane components. Orig Life Evol Biosph. 42:295-306.
Toppozini L, Dies H, Deamer DW, Rheinstädter MC (2013) Adenosine Monophosphate Forms Ordered Arrays in Multilamellar Lipid Matrices: Insights into Assembly of Nucleic Acid for Primitive Life. PLoS ONE 8(5): e62810.
Black RA, Blosser MC, Stottrup BL, Tavakley R, Deamer DW, Keller SL. 2013. Nucleobases bind to and stabilize aggregates of a prebiotic amphiphile, providing a viable mechanism for the emergence of protocells. Proc Natl Acad Sci U S A. 110:13272-6.
De Guzman V, Shenasa H, Vercoutere W, Deamer D (2014) Generation of oligonucleotides under hydrothermal conditions by non-enzymatic polymerization. J Mol Evol 78:251-262
Da Silva, L., Maurel, M.C., Deamer, D. (2014) Salt-promoted synthesis of RNA-like molecules in simulated hydrothermal conditions. J Mol Evol 80: 86 - 97.
Deamer D. 2012. Liquid crystalline nanostructures: organizing matrices for non-enzymatic nucleic acid polymerization. Chem Soc Rev. 41:5375-9.
Deamer, D. 2014. The Origin of Life. pp. 121-26. The Princeton Guide to Evolution, Princeton University Press.
Georgiou CD, Deamer DW. 2014. Lipids as universal biomarkers of extraterrestrial life. Astrobiology. 14:541-9. doi: 10.1089/ast.2013.1134
Deamer, D.W. and Szostak, J. (eds) 2010. Origins of Life. Cold Spring Harbor Press, NY.
Damer B, Deamer D. 2015. Coupled phases and combinatorial selection in fluctuating hydrothermal pools: a scenario to guide experimental approaches to the origin of cellular life. Life (Basel). 5:872-87. doi: 10.3390/life5010872.
Deamer, DW, Georgio CD. 2015. Hydrothermal Conditions and the Origin of Cellular Life. Astrobiology 15: 1091-1095. doi:10.1089/ast.2015.1338.
Deamer, D.W. 2011. First Life. University of California Press, Berkeley CA.