Glenn L Millhauser

TitleDistinguished Professor
DivisionPhysical & Biological Sciences
DepartmentChemistry & Biochemistry Department
AffiliationsBiomolecular Science & Engineering,
Microbiology & Environmental Toxicology
Web Site Millhauser Research Group
OfficePhysical Sciences Building 256
Office Hoursby appointment
Campus Mail StopChemistry
picture of Glenn L Millhauser

Research Interests

We use biophysical methods to study neurological proteins, their cofactors and how misregulation contributes to disease.

Biography, Education and Training

B.S., California State University, Los Angeles
Ph.D., Cornell University
Postdoc, Cornell University

Selected Publications

McDonald AJ, Millhauser GL. PrP overdrive: Does inhibition of α-cleavage contribute to PrPC toxicity and prion disease? Prion. 2014 Apr 10;8(2).

Spevacek AR, Evans EG, Miller JL, Meyer HC, Pelton JG, Millhauser GL. Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface. Structure. 2013 Feb 5;21(2):236-46.

Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C. Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR. Nat Chem Biol. 2012 Jun 24

Madonna ME, Schurdak J, Yang YK, Benoit S, Millhauser GL. Agouti-related protein segments outside of the receptor binding core are required for enhanced short- and long-term feeding stimulation. ACS Chem Biol. 2012 Feb 17;7(2):395-402.

Liu L, Jiang D, McDonald A, Hao Y, Millhauser GL, Zhou F., Copper redox cycling in the prion protein depends critically on binding mode. J Am Chem Soc. 2011 133(31):12229-37.

Levitan K, Chereau D, Cohen SI, Knowles TP, Dobson CM, Fink AL, Anderson JP, Goldstein JM, Millhauser GL., Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein, J Mol Biol. 2011 411(2):329-33.

Dudzik CG, Walter ED, Millhauser GL., Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease. Biochemistry. 2011 50(11):1771-7.

Patel MP, Cribb Fabersunne CS, Yang YK, Kaelin CB, Barsh GS, Millhauser GL., Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism. J Mol Biol. 2010 404(1):45-55.

Stevens DJ, Walter ED, Rodríguez A, Draper D, Davies P, Brown DR, Millhauser GL., Early onset prion disease from octarepeat expansion correlates with copper binding properties. PLoS Pathog. 2009 Apr;5(4):e1000390.

Walter ED, Stevens DJ, Visconte MP, Millhauser GL., The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modes. J Am Chem Soc. 2007 129(50):15440-1.

Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS., A beta-defensin mutation causes black coat color in domestic dogs. Science. 2007 318(5855):1418-23.

Courses Taught

Chemistry 1A
Chemistry 1B
Chemistry 163A
Chemistry 163C
Chemistry 200B