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Tentative Course Syllabus:
- Thermodynamics of
Organic Free Radicals
- Radical Stabilization,
Bond Dissociation Energies
- Resonance and
Electronic Stabilization
- Kinetics of Organic
Free Radicals
- Rate Constants
of Radical Processes
- "Radical
Clocks"
- Persistent Radicals
- Initiators to Generate
Free Radicals
- Free Radical Chain
Reactions
- Tin Hydride Based
Methodologies
- The Barton Method
- SH2
Reactions
- Atom (and
Group) Transfer
- Hydrogen Translocation
- Free Radical
Halogenation
- Stochiometric Free
Radical Reactions
- Metal Based Reactions:
SmI2 , Ni, Co, MnIII, CeIV, O-Stannyl Ketyl
- Non-metal Redox:
SET, PET, and Electrochemistry,
- Photoexcitation
to form biradicals
- photodeprotection
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- Radical Rearrangements
- Control of Stereochemistry
in Radical Reactions
- Control of Relative
Stereochemistry
- Beckwith Transition
State
- 1,2 diastereoselectivity
- Control of Absolute
Stereochemistry
- Chiral Auxiliaries
- Optically
Active Lewis Acids
- Free Radical Polymerization
- Uncontrolled
- Living Free Radical
Polymerization
- Nitroxide-mediated
- ATRP
- RAFT
- Free Radicals in Biology
- Bergman Diradicals
- Radical Damage
to DNA
- Amino Acid Radicals
- Protein free
radicals in enzyme active sites
- Role in aging
and Alzheimer’s
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There
will be no single text for the class: the bulk of the material covered
will come from the scientific literature. In addition, the following texts
are recommended as reference material:
P. Renaud and
M. Sibi, Ed. "Radicals in Organic Synthesis" (2 volume
set), Wiley-VCH, Weinheim, 2001.
M. J. Perkins "Radical Chemistry" Ellis, Horwood,
New York, 1994.
B. Giese "Radicals in Organic Synthesis: Formation of Carbon-Carbon
Bonds" Pergamon, Oxford, 1986.
D. P. Curran, N. A. Porter, B. Giese, "Stereochemistry of
Radical Reactions," VCH, Weinheim, 1996. |
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