Lokey lab publications
 
Turner RA, Oliver AG, Lokey RS. Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides. Org. Lett. 2007, 9, 5011-5014. Nehil MT, Tamble CM, Combs DJ, Kellogg DR, Lokey RS. Uncovering genetic relationships using small molecules that selectively target yeast cell cycle mutants. Chem. Biol. Drug Des. 2007, 69, 258-264. Schuresko LA, Lokey RS. A Practical Solid Phase Synthesis of Glu7-Phalloidin and Entry into Fluorescent F-Actin Binding Reagents. Angew. Chem. Int. Ed. 2007, 46, 3547-3549. Combs DJ, Lokey RS; Extended peptoids: a new class of oligomers based on aromatic building blocks. Tet. Lett. 2007, 48, 2679-82. Gassner NC, Tamble CM, Bock JE, Cotton M, White KN, Tenney K, St.Onge RP, Proctor MJ, Giaever G, Davis RW, Crews, P, Holman TR, Lokey RS; Accelerating the Discovery of Biologically Active Small Molecules Using a High-Throughput Yeast Halo Assay. J. Nat. Prod. 2007; Ralifo P, Sanchez L, Gassner NC, Tenney K, Lokey RS, Holman TR, Valeriote FA, Crews P; Pyrroloacridine Alkaloids from Plakortis quasiamphiaster: Structures and Bioactivity. J. Nat. Prod. 2007 70, 95-99 Rezai, T, Bock, JE, Vuong, Kalyanaraman K, C, Lokey RS*, Jacobson MP*. Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful In Silico Prediction of the Relative Permeabilities of Cyclic Peptides. J. Am. Chem. Soc. 2006; 128, 14073-14080 (*Corresponding authors). Rezai T, Yu B, Millhauser GL, Jacobson MP, Lokey RS. Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers. J. Am. Chem. Soc. 2006; 128, 2510-2511. Perlman ZE, Bock JE, Peterson JR, Lokey RS. Geometric Diversity Through Permutation of Backbone Configuration in Cyclic Peptide Libraries. Bioorg. Med. Chem. Lett. 2005; 15, 5329-5334. Simon RA, Schuresko L, Dendurkuri N, Goers E, Murphy B, Lokey RS. One-bead-one-compound library of end-capped dipeptides and deconvolution by microflow NMR. J. Combi. Chem. 2005, 7, 697-702. Lokey, R.S. “Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia.” Curr. Op. Chem. Biol. 2003, 7, 91-96.