Publicaciones

2009

Linington, R.G.; Clark, B.R.; Trimble, E.E.; Almanza, A.; Ureña, L.-D.; Kyle, D.E.; Gerwick, W.H. Antimalarial peptides from marine cyanobacteria: Isolation and structural elucidation of gallinamide A. Journal of Natural Products 2009, 72, 14-17.

2008

Capson, T.L. Biodiscovery research in Panama: Linking science, technology, human health, and conservation in the host-country context. In: Legal and Scientific Implications of Bioprospecting Contracts: A Handbook for Policymakers , Carrizosa, S.; McGuire, P. Eds. IUCN-Environmental Law Centre: IUCN, In Press .

Jimenez-Romero, C.; Ortega-Barria, E.; Arnold, A.E.; Cubilla-Rios, L. Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp. Pharmaceutical Biology 2008, In Press .

Kursar, T.A.; Capson, T.L.; Cubilla-Rios, L.; Emmen, D.A.; Gerwick, W.; Heller, M.V.; McPhail, K.; Ortega-Barria, E.; Quiros, D.I.; Romero, L.I.; Coley, P.D. Linking insights from basic research with bioprospecting in order to promote conservation, enhance research capacity and provide economic uses of biodiversity. In: Tropical Forest Community Ecology, Carson, W.; Schnitzer, S. Eds., Wiley-Blackwell, 2008, In Press .

Kursar, T.; Caballero-George, C.; Capson. T.L.; Cubilla-Rios, L.; Gerwick, W.; Ibanez, A.; Linington, R.; McPhail, K.; Ortega-Barria, E.; Romero, L.; Coley, P.D. Obtaining economic benefits from sustainably managed ecosystems through bioprospecting. In Press .

Coley, P.D. On turning green into gold. Daedalus 2008, Winter, 92-95.

Linington, R.G.; Edwards, D.J.; Shuman, C.F.; McPhail, K.L.; Matainaho, T.; Gerwick, W.H. Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine cyanobacterium Symploca sp. Journal of Natural Products 2008, 71, 22-27.

Medina, R.A.; Goeger, D.E.; Hills, P.; Mooberry, S.L.; Huang, N.; Romero, L.I.; Ortega-Barria, E.; Gerwick, W.H.; McPhail, K.L. Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp. Journal of the American Chemical Society 2008, 130, 6324-6325. 

2007

Jimenez-Romero, C.; Torres-Mendoza, D.; Urena-Gonzales, L.D.; Ortega-Barria, E.; McPhail, K.L.; Gerwick, W.H.; Cubilla-Rios, L. Hydroxy-alkenylresorcinols from Stylogyne turbacensis. Journal of Natural Products 2007,70, 1249-1252.

Kourtchenko, O.; Anderson, M.X.; Hamberg, M.; Brunnstroem, A.; Goebel, C.; McPhail, K.L.; Gerwick, W.H.; Feussner, I.; Ellerstroem, M. Oxo-phytodienoic acid-containing galactolipids in Arabidopsis: Jasmonate signaling dependence. Plant Physiology 2007, 145, 1658-1669.

Kursar, T.A.; Caballero-George, C.C.; Capson, T.L.; Cubilla-Rios, L.; Gerwick, W.H.; Heller, M.V.; Ibanez, A.; Linington, R.G.; McPhail, K.L.; Ortega-Barria, E.; Romero, L.I.; Coley, P.D. Linking bioprospecting with sustainable development and conservation: the Panama case. Biodiversity and Conservation 2007, 16 , 2789-2800.

Linington, R.G.; Gonzalez, J.; Urena, L.D.; Ortega-Barria, E.; Gerwick, W.H. Venturamides A and B: Antimalarial constituents of the Panamanian marine cyanobacterium Oscillatoria sp. Journal of Natural Products 2007, 70 , 397-401.

McPhail, K.L.; Correa, J.; Linington, R.G.; Gonzalez, J.; Ortega-Barria, E.; Capson, T.L.; Gerwick, W.H. Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products 2007, 70 , 984-988.

Montenegro, H.; Gonzalez, J.; Ortega-Barria, E.; Cubilla, L. Antiprotozoal activity of flavonoid glycosides isolated from Climedia sericea and Mosquitoxylon jamaicense. Pharmaceutical Biology 2007, 45 , 376-380.

Sanchez, L.A.; Capitan, Z.; Romero, L.I.; Ortega-Barria, E.; Gerwick, W.H.; Cubilla-Rios, L. Bio-assay guided isolation of germacranes with anti-protozoan activity from Magnolia sororum. Natural Product Communications 2007, 2 , 1065-1198.

Whibley, C.E.; McPhail, K.L.; Keyzers, R.A.; Maritz, M.F.; Leaner, V.D.; Birrer, M.J.; Davies-Coleman, M.T.; Hendricks, D.T. Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones. Molecular Cancer Therapeutics 2007, 6 , 2535-2543.

2006

Capson, T.L. Panama's Coiba National Park: a jewel of the tropical eastern Pacific. World Heritage 2006 , 42, 24-29.

Correa, J.E.; Rios, C.; Castillo, A.; Romero, L.I.; Ortega-Barria, E.; Coley, P.D.; Kursar, T.A.; Heller, M.V.; Gerwick, W.H.; Cubilla-Rios, L. Minor alkaloids from Guatteria dumentorum with antileishmanial activity. Planta Medica 2006, 72 , 270-272.

Gutierrez, M.; Capson, T.L.; Guzman, H.M.; Gonzalez, J.; Ortega-Barria, E.; Quinoa, E.; Riguera, R. Antiplasmodial metabolites isolated from the marine octocoral Muricea austera. Journal of Natural Products 2006, 69 , 1379-1383.

Kursar, T.A.; Caballero-George, C.G.; Capson, T.L.; Cubilla-Rios, L.; Gerwick, W.H.; Gupta, M.P.; Ibanez, A.; Linington, R.G.; McPhail, K.L.; Ortega-Barria, E.; Romero, L.I.; Solis, P.N.; Coley, P.D. Securing economic benefits and promoting conservation through bioprospecting. BioScience 2006,56 , 1005-1012.

Molinar-Toribio, E.; Gonzalez, J.; Ortega-Barria, E.; Capson, T.L.; Coley, P.D.; Kursar, T.A.; McPhail, K.L.; Cubilla-Rios, L. Antiprotozoal activity against Plasmodium falciparum and Trypanosoma cruzi of xanthones isolated from Chrysochlamys tenuis. Pharmaceutical Biology 2006, 44 , 550-553.

Quiros, D.; Emmen, D.A.; Dominguez, E.; Heller, M.V.; Coley, P.D.; Kursar, T.A. A rapid, efficient method for the bioassay of extracts, fractions and compounds for activity against tropical aphids. International Journal of Pest Management 2006, 52 , 333-342.

Simmons, T.L.; McPhail, K.L.; Orega-Barria, E.; Mooberry, S.L.; Gerwick, W.H. Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium. Tetrahedron Letters 2006, 47 , 3387-3390.

Torres-Mendoza, D.; Gonzalez, J.; Ortega-Barria, E.; Heller, M.V.; Capson, T.L.; Mcphail, K.L.; Gerwick, W.H.; Cubilla-Rios, L. Weakly antimalarial flavonol arabinofuranosides from Calycolpus warszewiczianus. Journal Natural Products 2006, 69 , 826-828.

2005

Cherigo, L.; Polanco, V.; Ortega-Barria, E.; Capson, T.L.; Cubilla-Rios, L. Anti-Trypanosoma cruzi activity of a norlignan purified from Nectandra lineate. Journal of Natural Products Research 2005, 19 , 373-377.

Garzon, S.P.; Rodriguez, A.D.; Sanchez, J.A.; Ortega-Barria, E. Sesquiterpenoid metabolites with antiplasmodial activity from a Caribbean gorgonian coral, Eunicea sp. Journal of Natural Products 2005, 68 , 1354-1359.

Gutierrez, M.; Capson, T.L.; Guzman, H.M.; Gonzalez, J.; Ortega-Barria, E.; Quinoa, E.; Riguera, R. Antiprotozoal activity against Plasmodium falciparum and Trypanosoma crusi of aeroplysinin-1 isolated from the new sponge Aplysina chiriquensis. Pharmaceutical Biology 2005,43 , 762-765.

Gutierrez, M.; Capson, T.L.; Guzman, H.M.; Gonzalez, J.; Ortega-Barria, E.; Quinoa, E.; Riguera, R. Leptolide, a new furanocembranolide diterpene from Leptogorgia alba. Journal of Natural Products 2005, 68 , 614-616.

Hussein, A.A.; Barberena, I.; Correa, M.; Coley, P.D.; Solis, P.N.; Gupta, M.P. Cytotoxic flavonol glycosides from Triplaris cumingiana. Journal of Natural Products 2005, 68 , 231-233.

Hussein, A.A.; Olmedo, D.A.; Vasquez, Y.; Coley, P.D.; Solis, P.N.; Gupta, M.P. New cytotoxic cinnamic acid derivatives from leaves of Bonamia trichantha. Revista Latinamerica de Quimica 2005, 32 , 90-96.

Ospina, C.A.; Rodriguez, A.D.; Sanchez, J.A.; Ortega-Barria, E.; Capson, T.L.; Mayer, A.M.S. Caucanolides A-F, unusual antiplasmodial constituents from a Colombian collection of the gorgonian coral Pseudopterogorgia bipinnata. Journal of Natural Products 2005, 68 , 1519-1526.

2004

Corbett, Y.; Herrera, L.; Gonzalez, J.; Cubilla-Rios, L.; Capson, T.L.; Coley, P.D.; Kursar, T.A.; Romero, L.I.; Ortega-Barria, E. A novel DNA-based microfluorimetric method to evaluate antimalarial drug activity. American Journal of Tropical Medicine and Hygiene 2004, 70 , 119-124.

Gutierrez, M.; Capson, T.L.; Guzman, H.M.; Quinoa, E.; Riguera, R. L-Galactose as a natural product: Isolation from a marine octocoral of the first alpha-L-galactosyl saponin. Tetrahedron Letters 2004, 45 , 7833-7836.

Hussein, A.A.; Barberena, I.; Capson, T.L.; Kursar, T.A.; Coley, P.D.; Solis, P.N.; Gupta, M.P. New cytotoxic naphthopyrane derivatives from Adenaria floribunda. Journal of Natural Products 2004, 67 , 451-453.

Marrero, J.; Rodriguez, A.D.; Baran, P.; Raptis, R.G.; Sanchez, J.; Ortega-Barria, E.; Capson, T.L. Bielschowskysin, a gorgonian-derived biologically active diterpene with an unprecedented carbon skeleton. Organic Letters 2004, 6 , 1661-1664.

Rodriguez, I.; Shi, Y.P., Garcia, O.J.; Rodriguez, A.D.; Mayer, A.M.S.; Sanchez, J.A.; Ortega-Barria, E.; Gonzalez, J. New pseudopterosin and seco-pseudopterosin diterpene glycosides from two Colombian isolates of Pseudopterogorgia elisabethae and their diverse biological activities. Journal of Natural Products 2004,67 , 1672-1680.

Torres-Mendoza, D.; Urena, L.D.; Gonzalez, J.; Ortega-Barria, E.; Coley, P.D.; Kursar, T.A.; Capson, T.L.; McPhail, K.L.; Cubilla-Rios, L. Novel cassane and cleistanthane diterpenes from Myrospermum frutescens: absolute stereochemistry of the cassane diterpene series. Journal of Natural Products 2004,67 , 1711-5.

Wei, X.; Rodriguez, A.D.; Baran, P.; Raptis, R.G.; Sanchez, J.A.; Ortega-Barria, E.; Gonzalez, J. Antiplasmodial cembradiene diterpenoids from a southwestern Caribbean gorgonian octocoral of the genus Eunicea . Tetrahedron 2004,60 , 11813-11819.

2003

Coley, P.D.; Heller, M.V.; Aizprua, R.; Arauz, B.; Flores, N.; Correa, M.; Gupta, M.; Solis, P.N.; Ortega-Barria, E.; Romero, L.I.; Gomez, B.; Ramos, M.; Cubilla-Rios, L.; Capson, T.L.; Kursar, T.A. Using ecological criteria to design plant collection strategies for drug discovery. Frontiers in Ecology and the Environment 2003, 8 , 421-428.

Hussein, A.A.; Gomez, B.; Ramos, M.; Heller, M.; Coley, P.D.; Solis, P.N.; Gupta, M.P. Constituents of Hiraea reclinata and their anti-HIV activity. Revista Latinoamerica de Quimica 2003, 31 , 74-77.

Hussein, A.A.; Bozzi, B.; Correa, M.; Capson, T.L.; Kursar, T.A.; Coley, P.D.; Solis, P.N.; Gupta, M.P. Bioactive constituents from three Vismia species. Journal of Natural Products 2003, 66 , 858-860.

Kursar, T.A.; Coley, P.D. Convergence in defense syndromes of young leaves in tropical rainforests. Biochemical Systematics and Ecology 2003,31 , 929-949.

Montenegro, H.; Gutierrez, M.; Romero, L.I.; Ortega-Barria, E.; Capson, T.L.; Cubilla-Rios, L. Aporphine Alkaloids from Guateria spp. with Leishmanicidal Activity. Planta Medica 2003, 69 , 677-679.

Ospina, C.A.; Rodriguez, A.D.; Ortega-Barria, E.; Capson, T.L. Briarellins J-P and polyanthellin A: New eunicellin-based diterpenes from the gorgonian coral Briareum polyanthes and their antimalarial activity. Journal Natural Products 2003, 66 , 357-363.

Rodriguez, N.; Vasquez, Y.; Hussein, A.A.; Coley, P.D.; Solis, P.N.; Gupta, M.P. Cytotoxic cucurbitacin constituents from Sloanea zuliaensis. Journal of Natural Products 2003, 66 , 1515-1516.

Torres-Mendoza, D.; Urena-Gonzalez, L.D.; Ortega-Barria, E.; Capson, T.L.; Cubilla-Rios, L. Five new cassane diterpenes from Myrospermum frutescens with activity against Trypanosoma cruzi. Journal of Natural Products 2003, 66 , 928-932.

Williams, C.; Espinosa, O.A.; Montenegro, H.; Cubilla, L.; Capson, T.L.; Ortega-Barria, E.; Romero, L. Hydrosoluble formazan XTT: its application to natural products drug discovery for Leishmania. Journal of Microbiological Methods 2003, 55 , 813-816.

2000

Arnold, A.E.; Maynard, Z.; Gilbert, G.S.; Coley, P.D.; Kursar, T.A. Are tropical fungal endophytes hyperdiverse? Ecology Letters 2000, 3 , 267-274.

1999

Kursar, T.A.; Capson T.L.; Coley, P.D.; Corley, D.G.; Gupta, M.P.; Harrison, L.A.; Ortega-Barria, E.; Windsor, D.M. Ecologically guided bioprospecting in Panama. Journal of Pharmaceutical Biology 1999, 37 (suppl.) , 114-126.

1996

Capson, T.L.; Coley, P.D.; Kursar, T.A. A new paradigm for drug discovery in tropical rainforests. Nature Biotechnology 1996, 14s, 1200, 1202.