Biochemistry and

Molecular Biology 100B

Winter 2003

Part One: Ligand-Binding, Enzyme Kinetics and Mechanisms

[Link for Part 2 will be added here when available]

Assigned Text: Berg, Tymoczko & Stryer, Biochemistry,5th Ed.

Additional resources:

Optional additional text for the eager: Zubay, Biochemistry.

Biochemistry in 3D -Lehninger Principles of Biochemistry

http://www.MoleculesInMotion.com

Coursemeets Tuesdays and Thursdays at 12:00 noon to 1:45 pm in

Social Sciences Building 2, Room 071

EXAM REVIEW:
This will be IN CLASS at 12:00-1:45 on Tuesday February 4th

Discussion Sections will meet according to the linked schedule.
However, there are currently three scheduled, but since only 34 students have enrolled,
it is likely we will have no more than two. This page was last updated on December 10, 2002.

Prof. William G. Scott
Office hours : Thursdays, 4:00-5:00 or by appointment. Please go to TA first.
228 Sinsheimer
Phone: x9-5367
Email: wgscott@chemistry.ucsc.edu Please put "BMB 100B" in the subject line so I won't lose it.

On problem 3 in problem set #2, assume that [P]=[Q]=0.

Lecture
Number
Date
Topic
Reading Assignment (in Stryer unless noted otherwise)
Homework Assignment

1
1/7
Principles of Chemical Catalysis
Review your elementary and P-chem texts.

2
1/9
Principles of Enzyme Catalysis
Chapter 8, sections 1 to 3, and this

3
1/14
Enzyme Kinetics: The basics
Michaelis-Menton Equation Derived
Ch 8. , sections 4-appendex, & tutorial

4
1/16
Enzyme Kinetics: Further Applications
Chapter 9, overview. My notes on enzyme inhibition

5
1/21
Ligand-binding and Allosteric Interactions
Chapter 10 and my notes
Problem set 1 is due

6
1/23
Allosteric Interactions. Hemoglobin Structure
Chapter 10 and my notes
Problem set 1 solutions (in full)

7
1/28
Enzyme Structure and Mechanism I
Chapter 9, read in detail.
Problem set 2 is due

8
1/30
Enzyme Structure and Mechanism II
Chapter 9, read in detail. further reading
Problem set 2 solutions

9
2/4
Protein Dynamics and Molecular Motors
Exam Review IN CLASS at 12:00-1:45
Chapter 34. See also this animation
Problem set 3 is due

10
2/6
Exam #1: Covers first half of course

Problem set 3 solutions

--
2/11
(no class, "advising day")

Course Policies: Please Read Course Announcements: Download Adobe Acrobat PDF reader return to the chemistry courses homepage

Lecture Number	Date	Topic	Reading Assignment (in Stryer unless noted otherwise)	Homework Assignment
1	1/7	Principles of Chemical Catalysis	Review your elementary and P-chem texts.
2	1/9	Principles of Enzyme Catalysis	Chapter 8, sections 1 to 3, and this
3	1/14	Enzyme Kinetics: The basics	Michaelis-Menton Equation Derived Ch 8. , sections 4-appendex, & tutorial
4	1/16	Enzyme Kinetics: Further Applications	Chapter 9, overview. My notes on enzyme inhibition
5	1/21	Ligand-binding and Allosteric Interactions	Chapter 10 and my notes	Problem set 1 is due
6	1/23	Allosteric Interactions. Hemoglobin Structure	Chapter 10 and my notes	Problem set 1 solutions (in full)
7	1/28	Enzyme Structure and Mechanism I	Chapter 9, read in detail.	Problem set 2 is due
8	1/30	Enzyme Structure and Mechanism II	Chapter 9, read in detail. further reading	Problem set 2 solutions
9	2/4	Protein Dynamics and Molecular Motors Exam Review IN CLASS at 12:00-1:45	Chapter 34. See also this animation	Problem set 3 is due
10	2/6	Exam #1: Covers first half of course		Problem set 3 solutions
--	2/11	(no class, "advising day")