Chemistry 103 Spring 2008
Biochemical Structures, Reactions, and Energetics
Last Updated: 3/31/08 12:26 PM
| Instructor: Prof. Thomas Schleich | Lecture: M, W, F, 9:30 AM – 10:40 AM | |
| Office: 252 PSB | Location: PSB 114 | |
| Phone: 831 - 459 - 2067 | Office Hours: W, 2:00 - 4:00 PM (or by appointment) |
Email: mailto:schleich@chemistry.ucsc.edu
Chemistry 103, Biochemical
Structure, Reactions, and Energetics, is a one-quarter survey
introduction to modern biochemistry. Emphasis will be placed on those fundamental topics pertinent to
the
biochemistry of living systems. Aspects
of molecular biology involving the flow of biological information will
not be
covered (DNA replication, repair, recombination, transcription,
translation,
recombinant DNA, and cloning technology) nor will photosynthesis. We will strive for an aggressive reading and
lecture schedule, roughly two-thirds of a chapter per lecture from the recommended text (Fundamentals of Biochemistry – Life at the
Molecular Level, Third Edition, by Voet, Voet,
and
Pratt) (ISBN-13 978-0470-12930-2) per lecture. If necessary, the
pace will be varied. Some topics may be
expanded whereas others may be truncated, condensed, or even eliminated.
Two take home exams will be given. The first will be approximately at mid quarter (Parts 1, 2, and 3 and Chap. 23 of the text) and the second at the conclusion of the quarter (Part 4 of text). In addition, a special project will be required and is due at the end of the quarter. Projects may take the following form: (1) Research paper on some aspect of biochemistry; (2) Analysis of a procedure to analyze some aspect of biochemistry; (3) Critique of a paper in the peer reviewed scientific literature; (4) Development of a computer program to enable investigation (modeling) of a biochemical process; (5) Other (by prior approval).
If you have a disability that interferes with your learning I encourage you to talk with me about it on a confidential basis so that we might collectively devise a strategy to overcome whatever barriers might exist. You should also consult with the Disability Resource Center .
Lecture Schedule
(subject to minor revision as the need arises)
Lecture Notes (requires Adobe Acrobat and Password)
DATE |
TOPIC |
READING |
3/31 |
Course Outline
|
Chapter 1 |
4/2 |
Physical Biochemistry of Water
|
Chapter 2 |
4/4 |
Amino Acids
|
Chapter 4 |
4/7 |
Proteins: Primary Structure
|
Chapter 5 (Parts 1, 3 & 4) |
4/9 |
Proteins: Three Dimensional Structure
|
Chapter 6 (Parts 1, 2 & 3) |
4/11 |
Proteins: Three Dimensional Structure
|
Chapter 6 (Parts 3, 4 & 5) |
4/14 |
Protein Function (Myoglobin and Hemoglobin)
|
Chapter 7 (Part 1) |
4/16 |
Enzymatic Catalysis |
Chapter 11 (Parts 1, 2 & 3)
|
4/18 |
Enzymatic Catalysis
|
Chapter 11 (Parts 4 & 5) |
4/21 |
Enzymatic Kinetics, Inhibition, and Control |
Chapter 12 (Parts 1 & 2)
|
4/23 |
Enzymatic Kinetics, Inhibition, and Control |
Chapter 12 (Parts 3 & 4) |
4/25 |
Carbohydrates
|
Chapter 8 |
4/28 |
Lipids and Biological Membranes
|
Chapter 9 (Parts 1 & 2) |
4/30 |
Lipids and Biological Membranes
|
Chapter 9 (Parts 3 & 4) |
5/2 |
Membrane Transport |
Chapter 10
|
5/5 |
Nucleic Acid Structure
|
Chapters 3 (Parts 1, 2 & 4) & 24 (Parts 1, 2 & 4) |
5/7 |
Introduction to Metabolism
|
Chapter 14 |
5/9 |
Glucose Metabolism
|
Chapter 15 (Parts 1, 2 & 3) |
5/12 |
Glucose Metabolism
|
Chapter 15 (Parts 4, 5 & 6) |
5/14 |
Glycogen Metabolism and Gluconeogenesis
|
Chapter 16 (Parts 1, 2 & 3) |
5/16 |
Glycogen Metabolism and Gluconeogenesis
|
Chapter 16 (Parts 4 & 5) |
5/19 |
Citric Acid (TCA) Cycle
|
Chapter 17 (Parts 1, 2 & 3) |
5/21 |
Citric Acid (TCA) Cycle
|
Chapter 17 (Parts 4 & 5) |
5/23 |
Electron Transport and Oxidative Phosphorylation
|
Chapter 18 (Parts 1 & 2) |
5/26 |
Holiday
|
|
5/28 |
Electron Transport and Oxidative Phosphorylation
|
Chapter 18 (Parts 3 & 4) |
5/30 |
Lipid Metabolism |
Chapter 20 (Parts 1 & 2) |
6/2 |
Lipid Metabolism
|
Chapter 20 (Parts 4, 5 & 7) |
6/4 |
Amino Acid Metabolism
|
Chapter 21 |
6/6 |
Mammaliam Fuel Metabolism
|
Chapter 22 |
|
Nucleotide Metabolism
|
Chapter 23 |
6/9 |
Project Due | |
Suggested
Study Strategy for Chemistry 103
Molecular Graphics Programs for Viewing Structures
WPDB - http://www.sdsc.edu/pb/wpdb/wpdb.htm
Protein
Explorer – http://molvis.sdsc.edu/protexpl/frntdoor.htm
Molecules in
Motion - http://www.moleculesinmotion.com/
Molecular
Visualization - http://www.umass.edu/microbio/rasmol/
Chime (molecular graphics plug-in for web browsers) - http://www.mdl.com/ (required for the software packages)