Department Faculty

Nikolaos Sgourakis
  • Title
    • Assistant Professor
  • Division Physical & Biological Sciences
  • Department
    • PBSci-Chemistry & Biochemistry Department
  • Phone
    831-459-3484 (Office), 831-502-7709 (Lab)
  • Email
  • Fax
    831-459-2935
  • Website
  • Office Location Physical Sciences Bldg 462 (Office), Physical Sciences Bldg 459 (Lab)
  • Mail Stop Chemistry
  • Mailing Address
    • 1156 High Street
    • Santa Cruz CA 95064
  • Faculty Areas of Expertise Chemistry

Summary of Expertise

Molecular & Structural Immunology; T cell receptor signaling dynamics; MHC-I peptide loading mechanism; Tumor neoantigen characterization (in collaboration with David Haussler’s BME group); Modeling protein complexes from sparse NMR data.

Biography, Education and Training

Our research focuses on elucidating the structures of important protein complexes involved in Immune recognition of viruses, bacterial secretion and neurodegeneration.

Determining the molecular basis of protein-protein interactions and self-assembly would help understand fundamental biological mechanisms and facilitate the design of novel therapeutics.

We are developing and implementing new structural biology tools based on Nuclear Magnetic Resonance spectroscopy and complementary sources of experimental data alongside advanced computational sampling methods. The integration of a range of experimental and computational approaches enables structural studies of proteins and their complexes at high resolution.